• Haemophilia · Jan 2007

    Case Reports

    Combined clotting factor deficiencies: experience at a single hemophilia treatment center.

    • S H O'Brien, A K Ritchey, and M V Ragni.
    • Division of Pediatric Hematology/Oncology, Columbus Children's Hospital, Columbus, OH 43205, USA. sarah.obrien@chp.edu
    • Haemophilia. 2007 Jan 1;13(1):26-9.

    AbstractWe describe a series of patients with combined factor deficiencies and von Willebrand's disease (VWD) at one haemophilia treatment centre. Although the incidence of VWD is at least 1% in the general population, combined coagulation defects have been infrequently described in the medical literature and are likely under diagnosed. This entity should be considered in patients with a known factor deficiency and either an unexpectedly severe bleeding phenotype, or bleeding that is unresponsive to factor replacement.

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