• Christopher P Landrigan, Jeffrey M Rothschild, John W Cronin, Rainu Kaushal, Elisabeth Burdick, Joel T Katz, Craig M Lilly, Peter H Stone, Steven W Lockley, David W Bates, and Charles A Czeisler.
• Division of Sleep Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. clandrigan@rics.bwh.harvard.edu
• N. Engl. J. Med. 2004 Oct 28;351(18):1838-48.

BackgroundAlthough sleep deprivation has been shown to impair neurobehavioral performance, few studies have measured its effects on medical errors.MethodsWe conducted a prospective, randomized study comparing the rates of serious medical errors made by interns while they were working according to a traditional schedule with extended (24 hours or more) work shifts every other shift (an "every third night" call schedule) and while they were working according to an intervention schedule that eliminated extended work shifts and reduced the number of hours worked per week. Incidents were identified by means of a multidisciplinary, four-pronged approach that included direct, continuous observation. Two physicians who were unaware of the interns' schedule assignments independently rated each incident.ResultsDuring a total of 2203 patient-days involving 634 admissions, interns made 35.9 percent more serious medical errors during the traditional schedule than during the intervention schedule (136.0 vs. 100.1 per 1000 patient-days, P<0.001), including 56.6 percent more nonintercepted serious errors (P<0.001). The total rate of serious errors on the critical care units was 22.0 percent higher during the traditional schedule than during the intervention schedule (193.2 vs. 158.4 per 1000 patient-days, P<0.001). Interns made 20.8 percent more serious medication errors during the traditional schedule than during the intervention schedule (99.7 vs. 82.5 per 1000 patient-days, P=0.03). Interns also made 5.6 times as many serious diagnostic errors during the traditional schedule as during the intervention schedule (18.6 vs. 3.3 per 1000 patient-days, P<0.001).ConclusionsInterns made substantially more serious medical errors when they worked frequent shifts of 24 hours or more than when they worked shorter shifts. Eliminating extended work shifts and reducing the number of hours interns work per week can reduce serious medical errors in the intensive care unit.Copyright 2004 Massachusetts Medical Society.

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