• Qin Gu, Zhang-hua Zhu, Min Ge, and Wei-hong Ge.
• Department of Intensive Care Unit, The Medical College of Nanjing University Affiliated Drum-Tower Hospital, Nanjing 210008, Jiangsu, China.
• Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2003 Feb 1;15(2):114-6.

ObjectiveTo investigate the pharmacokinetics of vancomycin in continuous veno-venous hemofiltration(CVVH) in order to determine appropriate vancomycin dosing strategies for patients receiving CVVH.MethodsThe serum concentrations of vancomycin were measured by TDx and the pharmacokinetics parameters were calculated.ResultsThe pharmacokinetics of vancomycin during CVVH was fitted with open two-compartment model. At the beginning of CVVH, the pharmacokinetic parameters were: maximum plasma concentration (Cmax)=22.18 mg/L, minimum plasma concentration attained (Cmin)=5.82 mg/L, half-life of drug (T1/2)=5.75 h, apparent volume of distribution (Vd)=21.92 L, total body clearance of drug(CL)=3.49 L/h. On the 16 d of CVVH, the pharmacokinetic parameters were Cmax=38.70 mg/L, Cmin=16.50 mg/L, T1/2=33.32 h, Vd=12.92 L, CL=0.38 L/h.ConclusionCVVH can significantly augment the clearance of vancomycin in acute renal failure patients. Dosing strategies for individualization of vancomycin therapy in patients receiving CVVH are proposed. Monitoring the serum concentration during CVVH is necessary.

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