• Expert Opin Drug Saf · Sep 2009

    Review

    Sodium-nitroprusside-induced cyanide toxicity in pediatric patients.

    • Christopher Thomas, Lindsay Svehla, and Brady S Moffett.
    • Texas Children's Hospital, Department of Pharmacy, 6621 Fannin Street, MC 2-2510, Houston, TX 77030, USA. bsmoffet@texaschildrenshospital.org
    • Expert Opin Drug Saf. 2009 Sep 1;8(5):599-602.

    BackgroundSodium nitroprusside (SNP) is often used as a continuous infusion intravenous vasodilator in pediatric patients. However, cyanide toxicity can occur with SNP therapy. Scant literature is available determining the safety of SNP therapy, the incidence of cyanide toxicity or the risk factors for cyanide toxicity in pediatric patients.ObjectiveTo review the literature concerning the safety of intravenous SNP with regard to cyanide toxicity in the pediatric patient population.MethodsA MedLine search was used to identify articles pertaining to SNP therapy and cyanide toxicity in pediatric patients.ConclusionsSodium nitroprusside seems to be safe when used in critically ill pediatric patients. Cyanide toxicity may occur in patients with specific risk factors. Routine monitoring of cyanide levels may not be warranted.

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