• Intensive care medicine · Nov 1999

    Septic shock without documented infection: an uncommon entity with a high mortality.

    • W J Reyes, S Brimioulle, and J L Vincent.
    • Dept of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium.
    • Intensive Care Med. 1999 Nov 1;25(11):1267-70.

    ObjectivesTo determine whether patients with clinically identified infection have the same outcome as patients with apparent sepsis but no identified infectious source.DesignRetrospective analysis of patient data.PatientsAll patients treated with septic shock in a 31-bed intensive care unit (ICU) over a 3-year period.ResultsData from 227 patients were analysed. Eighty-seven percent had a clinically identified source of infection. ICU mortality was higher in septic shock patients without a clinically identified source of infection than in those with an identified source of infection (86% versus 66%, p < 0.05).ConclusionsA small number of patients presenting with septic shock have no clinically identified infection. These patients have a higher mortality rate than patients in whom an infection is identified.

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