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Ugeskrift for laeger · May 2011
[Hyperfibrinolysis as the cause of haemorrhage and increased mortality in trauma patients].
- Anne Juul Wikkelsø, Arash Afshari, Jakob Stensballe, and Pär I Johansson.
- Anæstesiologisk Afdeling, Herlev Hospital, 2730 Herlev. wikkelso@gmail.com
- Ugeskr. Laeg. 2011 May 2;173(18):1284-7.
AbstractTrauma-associated coagulopathies are at times present upon arrival at the emergency department. Hyperfibrinolysis is a condition in which the natural ability to dissolve blood clots is pathologically enhanced. It is present in 2-8% of trauma patients and associated with shock and increased mortality. Hyperfibrinolysis is easily detected by thromboelastography. The condition is treated with antifibrinolytics such as tranexamic acid--whereas transfusion with blood products is inefficient. This article explores the mechanisms and diagnostics of hyperfibrinolysis in trauma patients and the relevant treatment options.
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