• S Klaus, L Bahlmann, J Gliemroth, M Heringlake, M Prüssmann, and P Schmucker.
• Klinik für Anästhesiologie und Intensivmedizin, Medizinische Universität zu Lübeck. stephan.klaus@epost.de
• Biomed Tech (Berl). 2001 Nov 1;46(11):304-6.

AbstractCurrently, metabolic changes in ICU patients in critical states are determined mainly by indirect laboratory parameters (e.g. blood lactate). Microdialysis is a new means of performing metabolic monitoring that permits organ-specific objectification on the basis of interstitial fluid samples. Continuous endotoxin infusion was administered to 10 female pigs and, in addition to hemodynamic monitoring, lactate and glycerol in the subcutaneous, intramuscular and hepatic tissue were measured by microdialysis. The interstitial concentrations of lactate and glycerol rose significantly under endotoxaemia and showed an earlier increase than blood lactate levels. Microdialysis is simple to apply, appears to be a suitable means of obtaining important information about cellular metabolic changes in different tissues of the critically ill patient, and can detect subtle changes that laboratory parameters can identify only later and incompletely.

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