• Per Flisberg, Malin Rundgren, and Martin Engström.
• Department of Anaesthesia and Intensive Care, Lund University Hospital, Lund, Sweden.
• Anesth. Analg. 2009 May 1;108(5):1430-2.

BackgroundIn this study, we assessed the immediate effects of platelet transfusion on whole blood coagulation.MethodsTen thrombocytopenic patients given a single unit platelet transfusion of 200-300 x 10(9) platelets had their coagulation status assessed before and immediately after transfusion using rotational thromboelastometry.ResultsTransfusion increased the median platelet count from 31.5 to 43.5 x 10(9)/L. Clot formation time decreased by 32% (P = 0.005), whereas maximum clot strength increased by 47% (P = 0.005).ConclusionStatistically significant improvements in rotational thromboelastometry-measured parameters were observed in association with a mean increase of 12 x 109/L in platelet count after platelet transfusion in these patients.

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