• Br. J. Pharmacol. · Aug 2004

    Comment

    Calcitonin gene-related peptide (CGRP) antagonists: blockers of neuronal transmission in migraine.

    • Susan D Brain.
    • Centre for Cardiovascular Biology and Medicine, King's College, Guy's Campus, London SE1 1UL. sue.brain@kcl.ac.uk
    • Br. J. Pharmacol. 2004 Aug 1;142(7):1053-4.

    AbstractThe neuropeptide calcitonin gene-related peptide (CGRP) is a potent vasodilator that is contained in and released from sensory nerves. CGRP has been implicated in migraine, and the nonpeptide CGRP antagonist BIBN4096BS has been shown to be effective in clinical trials in migraine. To date, it has been largely assumed that the CGRP antagonist is effective due to its ability to block vasodilator activity. Goadsby and co-workers present data that now suggest that CGRP antagonists may also block neuronal transmission in migraine.Copyright 2004 Nature Publishing Group

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