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Monaldi Arch Chest Dis · Sep 1994
ReviewAtelectasis formation and gas exchange impairment during anaesthesia.
- G Hedenstierna.
- Dept of Clinical Physiology, University Hospital, Uppsala, Sweden.
- Monaldi Arch Chest Dis. 1994 Sep 1;49(4):315-22.
AbstractAnaesthesia is accompanied by impaired oxygenation of the blood, and sometimes hypoxaemia may develop despite an increased oxygen fraction of the inspired gas. The major cause of this derangement is shunt, an effect of prompt atelectasis formation in dependent lung regions. An additional cause is ventilation/perfusion (V/Q) mismatch, possibly produced by intermittent airway closure. The magnitude of shunt and size of atelectasis are independent of the age of the patient, whereas V/Q mismatch increases with age, explaining the age dependent impairment of oxygenation.
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