• Maik J Grundeken, Xiaofei Li, C Eline Kurpershoek, Miranda C Kramer, Aryan Vink, Jan J Piek, Jan G P Tijssen, Karel T Koch, Joanna J Wykrzykowska, Robbert J de Winter, and Allard C van der Wal.
• From the Heartcenter (M.J.G., M.C.K., J.J.P., J.G.P.T., K.T.K., J.J.W., R.J.d.W.), and Department of Pathology (X.L., C.E.K., A.C.v.d.W.), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; and Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands (A.V.).
• Circ Cardiovasc Interv. 2015 Feb 1;8(2):e001816.

BackgroundCoronary guidewires are indispensable during percutaneous coronary interventions. Nowadays, most guidewires have hydrophilic coatings to improve their trackability, allowing easy lesion passage and facilitating balloon and stent positioning. Recent reports, however, have raised concerns about detachment and subsequent embolization of these hydrophilic coatings.Methods And ResultsWe have retrospectively reviewed the histological samples of the myocardium, obtained during autopsies in the period 2009 to 2013, from all patients who had a history of percutaneous coronary interventions (n=40). Foreign material was observed in the distal myocardium in 4 patients (10%). Furthermore, we have reviewed 205 thrombus specimens which were obtained during thrombus aspiration in the setting of primary percutaneous coronary interventions in the period 2005 to 2009. In 45% of the cases, foreign material was observed within the thrombus. Finally, we have examined the histopathologic appearance of hydrophilic-guidewire coating material ex vivo by embedding the coating in placenta specimen and cut and stain it in exactly the same manner as the myocardium and thrombus specimen. The histopathologic appearance of the hydrophilic coating ex vivo was identical to the foreign material found in vivo.ConclusionsDistal embolization of hydrophilic-coating material was observed in 10% of the patients who had a history of percutaneous coronary interventions. Hydrophilic-coating material was found in 45% of coronary thrombus specimen obtained during thrombus aspiration. These findings suggest that detachment and distal embolization of hydrophilic-coating material from coronary guidewires occur more often than the sparse literature on this topic suggests.© 2015 American Heart Association, Inc.

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