• Michael P Young, Valerie J Gooder, Karen McBride, Brent James, and Elliott S Fisher.
• University of Vermont College of Medicine, Division of Pulmonary and Critical Care, Burlington, Vt, USA. michael.young@vtmednet.org
• J Gen Intern Med. 2003 Feb 1; 18 (2): 778377-83.

ObjectiveTo examine if delayed transfer to the intensive care unit (ICU) after physiologic deterioration is associated with increased morbidity and mortality.DesignInception cohort.SettingCommunity hospital in Ogden, Utah.PatientsNinety-one consecutive inpatients with noncardiac diagnoses at the time of emergent transfer to the ICU. We determined the time when each patient first met any of 11 pre-specified physiologic criteria. We classified patients as "slow transfer" when patients met a physiologic criterion 4 or more hours before transfer to the ICU. Patients were followed until discharge.InterventionsNone.MeasurementsIn-hospital mortality, functional status at hospital discharge, hospital resources.Main ResultsAt the time when the first physiologic criterion was met on the ward, slow- and rapid-transfer patients were similar in terms of age, gender, diagnosis, number of days in hospital prior to ICU transfer, prehospital functional status, and APACHE II scores. By the time slow-transfer patients were admitted to the ICU, they had significantly higher APACHE II scores (21.7 vs 16.2; P =.002) and were more likely to die in-hospital (41% vs 11%; relative risk [RR], 3.5; 95% confidence interval [95% CI], 1.4 to 9.5). Slow-transfer patients were less likely to have had their physician notified of deterioration within 2 hours of meeting physiologic criteria (59% vs 31%; P =.001) and less likely to have had a bedside physician evaluation within the first 3 hours after meeting criteria (23% vs 83%; P =.001).ConclusionsSlow transfer to the ICU of physiologically defined high-risk hospitalized patients was associated with increased risk of death. Slow response to physiologic deterioration may explain these findings.

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