• Bozena Szyguła-Jurkiewicz, Romuald Wojnicz, Przemysław Trzeciak, Tomasz Niklewski, Marian Zembala, and Lech Poloński.
• III Katedra i Oddział Kliniczny Kardiologii, Slaskiej Akademii Medycznej, Kierownik Kliniki. b.szygula@sccs.pl
• Prz. Lek. 2005 Jan 1;62(5):265-9.

BackgroundEarly invasive strategy is one of alternative methods for management of acute coronary syndromes (ACS) without persistent ST-segment elevation.HypothesisThe aim of the study was analysis of clinical characteristics, in-hospital outcome and factors of in-hospital mortality.MethodsThe study group comprised 853 patients who were defined as high-risk, based on resting pain episodes within previous 24 hours, changes of ST-T segment in ECG, and elevated serum cardiac markers. All patients underwent coronary angiography followed by PCI (percutaneous coronary interventions) in 73.1% of patients. 16.7% were assigned to CABG (coronary artery bypass graft), 1.6% of patients underwent PCI and CABG and 8.6% of patients were treated conservatively.ResultsOverall in-hospital mortality was 3%; 1.4% in the PCI group, 8.4% in the CABG group and 6.8% in conservatively treated patients. The independent risk factors of in-hospital deaths were: Braunwald's IIIC class angina (OR 7.8; 95%CI 3.6-12.37 p=0.004), recurrent angina after revascularization (OR 13.04; 95%CI 7.62-29.23 p=0.002), congestive heart failure (OR 11.45; 95%CI 8.01-18,38 p=0.00001) and evolving myocardial infarction with ST-segment elevation (OR 12.77; 95%CI 8.35-27.35 p=0.0001). Stent implantation was associated with decreased risk of in-hospital death (OR 0.12; 95%CI 0.07-0.41; p=0.003).ConclusionsEarly invasive strategy in patients with ACS without ST-segment elevation is efficacious method of treatment. Independent predictors of in-hospital deaths are: Braunwald's IIIC class angina, congestive heart failure, recurrent angina after revascularization, myocardial infarction complicating hospital course. Stent implantation improves in-hospital prognosis.

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