• Clinics in perinatology · Sep 2013

    Review

    Genetic contributions to labor pain and progress.

    • Ruth Landau.
    • Department of Anesthesiology and Pain Medicine, University of Washington Medical Center, 1959 NE Pacific Street, Seattle, WA 98195-6540, USA. rulandau@u.washington.edu
    • Clin Perinatol. 2013 Sep 1;40(3):575-87.

    AbstractStudies on genetic contributions to labor analgesia have essentially evaluated the μ-opioid receptor gene (OPRM1), with some evidence that p.118A/G of OPRM1 influences the response to neuraxial opioids. As for labor progress, the β2-adrenergic receptor gene (ADRB2) is associated with preterm labor and delivery, and impacts the course of labor. Taken together though, there is no evidence that pharmacogenetic testing is needed or beneficial in the context of obstetric anesthesia; however, realizing the influence of genetic variants on specific phenotypes provides the rationale for a more cautious interpretation of clinical studies that attempt to find a dose-regimen that fits all.Copyright © 2013 Elsevier Inc. All rights reserved.

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