• Mitsuru Honda, Kyosuke Yokota, Ryo Ichibayashi, Katsunori Yoshihara, Hiroyuki Masuda, Hiroyuki Uekusa, Yoshikatsu Seiki, Jun Nomoto, Takeki Nagao, Taichi Kishi, and Shigeru Sase.
• Department of Critical Care Center, Toho University Medical Center, Omori Hospital, Ota-ku, Tokyo, Japan.
• Asian J Neurosurg. 2012 Apr 1;7(2):61-5.

AimsNeurointensive care has reduced the mortality and improved the outcome of patients for severe brain damage, over recent decades, and made it possible to perform this therapy in safety. However, we have to understand the complications of this therapy well. The purpose of our study was to determine the systemic circulation disturbance during the initiation of therapeutic hypothermia by using this continuous neurointensive monitoring system.Materials And MethodsTen severe brain damage patients treated with hypothermia were enrolled. All patients had Glasgow Coma Scale (GCS) less than or equal to 8, on admission.ResultsWe verified that heart rate, cardiac output, and oxygen delivery index (DO2I) decreased with decreasing core temperature. We recognized that depressed cardiac index (CI) was attributed to bradycardia, dehydration, and increased systemic vascular resistance index (SVRI) upon initiation of hypothermia.ConclusionAlthough the hypothermia has a therapeutic role in severe brain damage patients, we have to carry out this therapy while maintaining their cardiac output using multimodality monitoring devices during hypothermia period.

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