• Pediatric neurology · Jan 1993

    Guillain-Barré syndrome in childhood: natural course and efficacy of plasmapheresis.

    • P W Jansen, R M Perkin, and S Ashwal.
    • Department of Pediatrics, Loma Linda University School of Medicine, CA 92354.
    • Pediatr. Neurol. 1993 Jan 1;9(1):16-20.

    AbstractEight children with Guillain-Barré syndrome were treated with plasmapheresis. Retrospective comparisons were made with 11 historic control patients. Eight children required mechanical ventilation, 4 of whom were in the plasmapheresis group. One week after the last plasmapheresis treatment, patients receiving plasmapheresis within 7 days of symptom onset had improved by one Guillain-Barré syndrome score. Discharge Guillain-Barré syndrome scores were significantly lower for those receiving plasmapheresis (P < .05). Patients in the plasmapheresis group had a decrease in the number of days of mechanical ventilation, time until motor recovery, and overall cost. Our results are consistent with published literature and indicate that plasmapheresis for childhood Guillain-Barré syndrome is a safe and effective treatment to shorten the time to recovery.

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