• Kim Pauwels, Isabelle Huys, Minne Casteels, and Steven Simoens.
• KU Leuven Department of Pharmaceutical and Pharmacological Sciences, Onderwijs en Navorsing 2, Herestraat 49, P,O, Box 521, 3000 Leuven, Belgium. Kim.Pauwels@pharm.kuleuven.be.
• Bmc Health Serv Res. 2014 Jan 1;14:438.

BackgroundDrug shortages are a global problem. While extensively studied in the United States, numbers about drug shortages in European countries are scarce. This study aims to collect and present data about drug shortages in European countries.MethodsA reporting template for the collection of data about drug shortages was designed based on a literature search. Countries offering a reporting system for drug shortages such as Belgium, the Netherlands, England, Italy, France, Germany and Spain were included in this study. Data about the characteristics of the drugs in shortage and the causes of the shortage were collected from publicly available online reporting systems. Descriptive analyses were performed.ResultsDrug shortages included in the considered reporting systems can be characterized as branded, oral drugs that affect different disease domains. When considering essential medicines and oncology drugs, generic injectables are more involved. Causes for drug shortages are largely underreported. In case the cause is known, production problems take the lead.ConclusionsReporting of drug shortages in Europe needs to be standardized and more transparency about the reasons for drug shortage is required to investigate the problem. A link between production problems and market attractiveness and market capacity is recognized to be at the root of drug shortages in U.S. Such insights are highly lacking in Europe. Monitoring of the effect of national and European health policies on the sustainability of the drug market is required to present fundamental solutions and to tackle the problem of drug shortages in Europe.

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