• Anesthesia and analgesia · Apr 2008

    Case Reports

    Extracorporeal membrane oxygenation with danaparoid sodium after massive pulmonary embolism.

    • Christian Bauer, Zuzana Vichova, Patrick Ffrench, Christiane Hercule, Olivier Jegaden, Olivier Bastien, and Jean-Jacques Lehot.
    • Université Claude Bernard Lyon 1, France. christian.bauer@chu-lyon.fr
    • Anesth. Analg. 2008 Apr 1;106(4):1101-3, table of contents.

    AbstractDuring extracorporeal membrane oxygenation, anticoagulation therapy is usually achieved with unfractionated heparin. We report on an extracorporeal membrane oxygenation with danaparoid sodium for a patient with severe respiratory failure due to massive pulmonary embolism and suspected type 2 heparin-induced thrombocytopenia. Danaparoid, a low molecular weight heparinoid, is an alternative to heparin for patients who develop type 2 heparin-induced thrombocytopenia. Danaparoid was given at 400 IU/h with an objective of antifactor Xa activity of 0.6-0.8 U/mL, which was monitored twice a day. No excessive bleeding or clotting of the circuit was noted. The patient was weaned from extracorporeal membrane oxygenation after 9 days of treatment.

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