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Clinical Trial Controlled Clinical Trial
Absence of opioid withdrawal symptoms in patients receiving methadone and the protease inhibitor lopinavir-ritonavir.
- Susan Clarke, Fiona Mulcahy, Colm Bergin, Helen Reynolds, Nicola Boyle, Michael Barry, and David J Back.
- GenitoUrinary Medicine and Infectious Diseases Clinic, St. James's Hospital, Dublin, Ireland. Susan.Clarke@bmc.org
- Clin. Infect. Dis. 2002 Apr 15;34(8):1143-5.
AbstractA study was designed to determine the interactions, both clinical and pharmacokinetic, between methadone and lopinavir-ritonavir. Results demonstrated a 36% reduction in the methadone area under the plasma concentration-time curve after the introduction of lopinavir-ritonavir, with no coincident symptoms of opioid withdrawal and no requirement for methadone dose adjustment.
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