• J. Forensic Sci. · Jul 2007

    Case Reports

    A case of fatal intoxication from metformin.

    • Veniero Gambaro, Lucia Dell'acqua, Fiorenza Farè, Marco Fidani, Rino Froldi, and Elisa Saligari.
    • Institute of Pharmaceutical and Toxicological Chemistry, University of Milan, Viale Abruzzi 42, 20131 Milano, Italy. veniero.gambaro@unimi.it
    • J. Forensic Sci. 2007 Jul 1;52(4):988-91.

    AbstractA case of fatal intoxication from metformin is presented. The decedent was an obese 58-year-old-woman with type II diabetes, in whom severe lactic acidosis secondary to metformin accumulation was precipitated by acute renal failure. She had been on metformin 500 mg twice a day. Postmortem blood was deproteinated with acetonitrile, washed with dichloromethane, and the resulting supernatant injected into high-performance liquid chromatography system. Separation was performed on a analytical 125 x 4 mm i.d. RP-8 column. The wavelength was set at 235 nm. The mobile phase was acetonitrile (40%), sodium lauryl sulfate, and sodium dihydrogen phosphate adjusted to pH 5.1 (60%) at a flow rate of 1.0 mL/min. The concentration of metformin in postmortem blood was 77.3 microg/mL. The qualitative result was also confirmed by LC/APCI/MS/MS analysis.

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