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Review Case Reports
Potentiation of acetaminophen hepatotoxicity by phenytoin, leading to liver transplantation.
- Scott M Suchin, David C Wolf, Young Lee, Gita Ramaswamy, Patricia A Sheiner, Marcelo Facciuto, Michael R Marvin, Leona Kim-Schluger, and Edward Lebovics.
- Division of Gastroenterology and Hepatobiliary Diseases, Department of Surgery, New York Medical College, Westchester Medical Center, Valhalla, New York, USA. suchinmdrn@aol.com
- Dig. Dis. Sci. 2005 Oct 1;50(10):1836-8.
AbstractWe report the case of a 22-year-old man who developed fulminant hepatic failure 3 days after an intentional acetaminophen overdose. The patient had a history of a seizure disorder for which he was taking phenytoin. The acetaminophen level at presentation was in the "nontoxic" range. Emergent liver transplantation was performed 4 days after the ingestion. This is the first reported case of successful liver transplantation for acetaminophen-induced fulminant hepatic failure in the setting of phenytoin therapy.
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