• J. Cardiovasc. Electrophysiol. · Sep 2003

    Comparative Study

    Issues in subgroup analyses and meta-analyses of clinical trials.

    • J Thomas Bigger.
    • Departments of Medicine and Pharmacology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA. jtb2@columbia.edu
    • J. Cardiovasc. Electrophysiol. 2003 Sep 1;14(9 Suppl):S6-8.

    AbstractThis commentary discusses two techniques commonly used to analyze clinical trials: subgroup analysis and meta-analysis. Subgroup analysis is used to evaluate the consistency of a treatment across multiple groups, usually within a clinical trial. Subgroup analysis often is used to generate or test an hypothesis about risk factors or treatment responses. Meta-analysis (overview) is used primarily to summarize data from several randomized clinical trials and to evaluate consistency among trials. Meta-analysis is a formal way of summarizing the totality of information coming from well-conducted randomized clinical trials. The use and limitations of these two techniques are discussed.

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