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British medical journal · Jan 1974
Sensitivity to intravenous anaesthetics: a report of three cases.
- J W Dundee, E S Assem, J M Gaston, S R Keilty, J A Sutton, R S Clarke, and D Grainger.
- Br Med J. 1974 Jan 12;1(5897):63-5.
AbstractThree patients with sensitivity to an intravenous anaesthetic-thiopentone, propanidid, and Althesin (alphadolone and alphaxalone)-are described. In the cases of thiopentone and Althesin the reaction was characterized by cardiovascular collapse, while bronchospasm also occurred with thiopentone. The reaction to propanidid was a direct skin sensitivity. All patients had a personal or family history of asthma and all had been previously exposed to the offending drug. A leucocyte challenge test showed an allergic response to thiopentone and Althesin in two patients but gave a negative result in the patient with the skin reaction. Allergic reactions can occur to all types of intravenous anaesthetics in a few patients.
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