• Diagn Interv Radiol · Mar 2014

    Review Historical Article

    Irreversible electroporation: evolution of a laboratory technique in interventional oncology.

    • Amy R Deipolyi, Alexander Golberg, Martin L Yarmush, Ronald S Arellano, and Rahmi Oklu.
    • From the Department of Imaging, Division of Interventional Radiology (A.R.D., R.S.A., R.O. e-mail: roklu@mgh.harvard.edu) and the Center for Engineering in Medicine (A.G., M.L.Y., R.O.), Massachusetts General Hospital, Harvard Medical School, Boston, USA.
    • Diagn Interv Radiol. 2014 Mar 1;20(2):147-54.

    AbstractElectroporation involves applying electric field pulses to cells, leading to the alteration or destruction of cell membranes. Irreversible electroporation (IRE) creates permanent defects in cell membranes and induces cell death. By directly targeting IRE to tumors, percutaneous nonthermal ablation is possible. The history of IRE, evolution of concepts, theory, biological applications, and clinical data regarding its safety and efficacy are discussed.

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