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Case Reports
Tenofovir-associated Fanconi syndrome in patients with chronic hepatitis B monoinfection.
- David M Gracey, Paul Snelling, Paul McKenzie, and Simone I Strasser.
- Renal Unit, Royal Prince Alfred Hospital, Sydney, Australia. david.gracey@sswahs.nsw.gov.au.
- Antivir. Ther. (Lond.). 2013 Jan 1;18(7):945-8.
AbstractTenofovir disoproxil fumarate (TDF) is increasingly used in patients with chronic hepatitis B (CHB) infection. Although associated with renal toxicity in HIV-infected patients, renal dysfunction has been reported rarely in the monoinfected CHB population. To date, TDF-associated Fanconi syndrome has not been reported. Here, we present two cases of TDF-associated Fanconi syndrome with rapid resolution after its cessation. We then discuss risk factors for TDF nephrotoxicity and its implications for screening for renal disease in those patients with CHB monoinfection on TDF, and the use of TDF in at-risk populations.
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