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Case Reports
Administration of intravenous tissue plasminogen activator in a pediatric patient with acute ischemic stroke.
- Marwan I Shuayto, J Ivan Lopez, and Frank Greiner.
- Department of Neurology, University of South Alabama, College of Medicine, Mobile 36693, USA. M_Shuayto_MD@yahoo.com
- J. Child Neurol. 2006 Jul 1;21(7):604-6.
AbstractIntravenous tissue plasminogen activator is the only therapy approved by the US Food and Drug Administration (FDA) for the treatment of acute ischemic strokes. The National Institutes of Health (NIH)-sponsored study that led to the approval of tissue plasminogen activator to be used in acute ischemic strokes included only individuals 18 years of age and older. We report a case of a pediatric patient who suffered a dominant-hemisphere acute ischemic stroke who was treated with intravenous tissue plasminogen activator. Our patient's symptoms began to resolve 4 hours after treatment, and he had a complete recovery after 8 hours. The clinical outcome was excellent and without complications. Tissue plasminogen activator administration can be safe and effective in younger patients. Randomized, controlled, double-blind studies are needed.
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