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Clinical therapeutics · Dec 2012
Letter Comparative StudyOutcomes of extended-infusion piperacillin-tazobactam: a retrospective analysis of critically ill patients.
- Grace C Lee, Hansheng Liou, Russell Yee, Clifford F Quan, and Katherine Neldner.
- Clin Ther. 2012 Dec 1;34(12):2297-300.
AbstractStudies evaluating the outcomes of an extended-infusion (EI) piperacillin-tazobactam dosing strategy in specific cohorts of critically ill patients are lacking. A retrospective, pre-implementation and post-implementation study of 148 critically ill patients was conducted to compare EI and traditional infusion piperacillin-tazobactam. In this retrospective study, the EI piperacillin-tazobactam dosing strategy was associated with improved 30-day mortality. EI piperacillin-tazobactam may be an effective alternative to TI of piperacillin-tazobactam among critically ill patients treated for suspected gram-negative infections.Copyright © 2012 Elsevier HS Journals, Inc. All rights reserved.
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