• Critical care clinics · Apr 2011

    Coagulation biomarkers in critically ill patients.

    • Marcel Levi, Marcus Schultz, and Tom van der Poll.
    • Department of Vascular Medicine and Internal Medicine, Academic Medical Centre F-4, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. m.m.levi@amc.uva.nl
    • Crit Care Clin. 2011 Apr 1;27(2):281-97.

    AbstractThis article discusses coagulation biomarkers in critically ill patients where coagulation abnormalities occur frequently and may have a major impact on the outcome. An adequate explanation for the cause is important, since many underlying disorders may require specific treatment and supportive therapy directed at the underlying condition. Deficiencies in platelets and coagulation factors in bleeding patients or patients at risk for bleeding can be achieved by transfusion of platelet concentrate or plasma products, respectively. Prohemostatic treatment may be beneficial in case of severe bleeding, whereas restoring physiological anticoagulant pathways may be helpful in patients with sepsis and disseminated intravascular coagulation.Copyright © 2011 Elsevier Inc. All rights reserved.

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