• Acta paediatrica · Jun 2004

    Review Case Reports

    Linear IgA bullous dermatosis of neonatal onset: case report and review of the literature.

    • Y Kishida, J Kameyama, M Nei, T Hashimoto, and K Baba.
    • Department of Pediatrics, Kurashiki Central Hospital, Kurashiki City, Okayama, Japan. yk7924@kchnet.or.jp
    • Acta Paediatr. 2004 Jun 1;93(6):850-2.

    UnlabelledSeveral small blisters were noticed on the forehead and the trunk of a newborn boy on day 1. The blisters gradually enlarged and spread over the whole body including the oral mucosa. A skin biopsy was performed twice and subepidermal bullae with polymorphonuclear and mononuclear cell infiltration were demonstrated. Direct immunofluorescence showed linear IgA, IgG and C3 depositions along the basement membrane zone and this finding led to a diagnosis of linear IgA bullous dermatosis. So far, internationally, only one case has ever been reported on the disease at neonatal onset. The skin lesions spontaneously regressed and the mucosal lesions were controlled with diaminodiphenylsulfone.ConclusionIn neonates with prolonged blistering, autoimmune disease such as linear IgA bullous dermatosis should be considered within the differential diagnosis and an immunofluorescence study must be performed.

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