• Intensive care medicine · Jan 1994

    Review

    Role of hypoxic pulmonary vasoconstriction in pulmonary gas exchange and blood flow distribution. 1. Physiologic concepts.

    • B E Marshall, C Marshall, F Frasch, and C W Hanson.
    • Center for Anesthesia Research, University of Pennsylvania School of Medicine, Philadelphia 19104.
    • Intensive Care Med. 1994 Jan 1;20(4):291-7.

    AbstractThe regulation of the distribution of ventilation/perfusion ratios by hypoxic pulmonary vasoconstriction contributes to both the efficiency of gas exchange and to pulmonary hemodynamics. In this review, the first of two part series, are summarized the physiologic principles on which the analysis of ventilation/perfusion ratios and of pressure-flow relationships are based. A new combined analysis is introduced that permits the important contributions of hypoxic pulmonary vasoconstriction to overall gas exchange to be demonstrated in the circumstances of clinical complexity.

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