• Raquel A Caserta, Alexandre R Marra, Marcelino S Durão, Cláudia Vallone Silva, Oscar Fernando Pavao dos Santos, Henrique Sutton de Sousa Neves, Michael B Edmond, and Karina Tavares Timenetsky.
• Intensive Care Unit, Hospital Israelita Albert Einstein, Av, Albert Einstein, 627/701 - 5º Andar - Bloco B, São Paulo, CEP 05651-901, Brazil. raquel_case@eintein.br
• Bmc Infect Dis. 2012 Jan 1;12:234.

BackgroundVentilator-associated pneumonia (VAP) is a common infection in the intensive care unit (ICU) and associated with a high mortality.MethodsA quasi-experimental study was conducted in a medical-surgical ICU. Multiple interventions to optimize VAP prevention were performed from October 2008 to December 2010. All of these processes, including the Institute for Healthcare Improvement's (IHI) ventilator bundle plus oral decontamination with chlorhexidine and continuous aspiration of subglottic secretions (CASS), were adopted for patients undergoing mechanical ventilation.ResultsWe evaluated a total of 21,984 patient-days, and a total of 6,052 ventilator-days (ventilator utilization rate of 0.27). We found VAP rates of 1.3 and 2.0 per 1,000 ventilator days respectively in 2009 and 2010, achieving zero incidence of VAP several times during 12 months, whenever VAP bundle compliance was over 90%.ConclusionThese results suggest that it is possible to reduce VAP rates to near zero and sustain these rates, but it requires a complex process involving multiple performance measures and interventions that must be permanently monitored.

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