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Anaesth Intensive Care · Nov 1990
Does suxamethonium influence the subsequent dose requirements of alcuronium and its reversibility in children?
- T C Brown, O A Meretoja, D Clare, and B Bell.
- Royal Children's Hospital, Parkville, Victoria, Australia.
- Anaesth Intensive Care. 1990 Nov 1;18(4):479-82.
AbstractSuxamethonium is often used for intubation prior to the use of a nondepolarizing muscle relaxant. This study was performed to determine whether suxamethonium altered the dose of alcuronium required to produce neuromuscular block. The findings were that suxamethonium 1.0 mg/kg did not alter the depth, duration or reversibility of block if given before alcuronium 0.3 mg/kg. Reversal with neostigmine was more rapid following 50 micrograms/kg than after 25 micrograms/kg. If recovery from neuromuscular block was greater than 25 per cent, the lower dose produced satisfactory reversal, whether or not suxamethonium had been given previously.
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