• M Lanz, B Oehl, A Brandt, and A Schulze-Bonhage.
• Epilepsy Centre, University Hospital Freiburg, Breisacher Str. 64, 79106 Freiburg im Breisgau, Germany. michael.lanz@uniklinik-freiburg.de
• Seizure. 2011 Mar 1;20(2):167-72.

AbstractIctal-related cardiac asystole is supposed to be a risk factor for sudden unexpected death in epilepsy (SUDEP). We retrospectively analyzed the occurrence of ictal asystole in 2003 epilepsy patients undergoing long-term video EEG/ECG monitoring from 1/1999 to 6/2010 at the Freiburg epilepsy centre. Seven patients had cardiac arrest with a duration of at least 3s; 6 ictal, one postictal. In all patients, the temporal lobe was involved in ictal activity based on neurophysiological investigations or morphological lesion. Whereas asystole was self-limited in six cases, one patient with insular seizure origin had to undergo cardiopulmonary resuscitation. Interestingly, also patients with a short history of epilepsy, low seizure frequency and under treatment in monotherapy showed episodes of asystole. In all cases, even with brief cardiac arrest, asystole was associated with subsequent EEG flattening. In conclusion, ictal asystole is a rare event even in a population undergoing major changes in antiepileptic medication. Temporal lobe epilepsy was associated with a risk for asystole; cardiac arrest also occurred in patients who, based on their history, might have not been considered at elevated risk for SUDEP.Copyright © 2010 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

24 keywords...

hide…