• Mod. Pathol. · Nov 1993

    Case Reports

    Multicentric Castleman's disease in a child with prominent thymic involvement: a case report and brief review of the literature.

    • P E O'Reilly, V V Joshi, C T Holbrook, and D D Weisenburger.
    • Department of Pathology, East Carolina University School of Medicine, Greenville, North Carolina.
    • Mod. Pathol. 1993 Nov 1;6(6):776-80.

    AbstractA fatal case of multicentric Castleman's disease (giant lymph node hyperplasia) with prominent thymic involvement in a 12-yr-old girl is presented. Multicentric Castleman's disease is a poorly understood lymphoproliferative disorder generally occurring in elderly individuals. To our knowledge, this is the first case in the English literature of multicentric Castleman's disease in a child. Thymic involvement has not been described previously in the multicentric variant or in a child. Besides the characteristic findings of Castleman's disease (CD), such as hyaline-vascular follicles and a prominent plasmacytic infiltrate, the thymus was also marked by prominent epithelial hyperplasia in the medulla. The clinical and pathologic findings are presented with a review of the literature, particularly thymic involvement in CD and CD in the pediatric population.

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