• Suat Zengin, Mehmet Yılmaz, Behcet Al, Cuma Yildirim, Erdal Yavuz, and Aycan Akcali.
• Department of Emergency, Gaziantep University School of Medicine, Gaziantep, Turkey.
• J Clin Apher. 2013 Oct 1;28(5):337-40.

Background And ObjectiveCarbon monoxide (CO) is the most common cause of fatal poisoning worldwide. Therapeutic red cell exchange (TREX) has been used in the treatment of many different diseases. Therefore, we aimed to evaluate the efficacy of TREX on the clinical status, outcome, and discharge of patients with severe CO poisoning.MethodsDemographic data, clinical status, and outcomes of 12 patients that were treated with TREX for severe CO poisoning after referral to the Emergency and Hematology Departments of Gaziantep University between November 2011 and April 2012 were evaluated.ResultsMean carboxyhemoglobin level decreased from (59.7 ± 12.7)% (38-79%) to (17 ± 9.4)% (8-43%), and mean Glasgow Coma Scale score increased from 4 ± 1.6 (3-8) to 9.4 ± 3.5 (3-14) after TREX therapy. Five patients were admitted to the intensive care unit. Rhabdomyolysis developed in one case. Of the 12 patients, 11 were discharged alive, and one patient died.ConclusionTREX may be an alternative treatment method for reducing mortality and morbidity in cases of severe CO poisoning.Copyright © 2013 Wiley Periodicals, Inc.

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