• Anesteziol Reanimatol · Mar 2008

    [Effect of sevoflurane on spontaneous brain bioelectrical activity in neurosurgical patients].

    • D A Moshchev, O B Sazonova, A A Ogurtsova, and A Iu Lubnin.
    • Anesteziol Reanimatol. 2008 Mar 1(2):11-6.

    AbstractThe present study was undertaken to evaluate the effects of sevoflurane on spontaneous brain bioelectrical activity in neurosurgical patients. Forty patients treated at the Research Institute of Neurosurgery underwent a neurophysiological examination. No epileptic syndrome was revealed in the clinical picture in 10 patients (a control group), the remaining 30 patients had a history of varying epileptic seizures of different degrees and frequency. Sevoflurane causes a relative acceleration of epileptiform activity synchronization, as evidenced by EEG, which is not a contraindication to the use of this drug in patients with cerebral organic lesion of various genesis with a history of epileptic syndrome and fails to induce clinically significant EEG epileptiform manifestations in patients without epilepsy. In patients with cerebrovascular abnormalities (arteriovenous malformation, cavernous angiomas) who have a history of paroxysmal conditions, inhalational sevoflurane anesthesia can be performed in combination with anticonvulsants (benzodiazepines) during an operation.

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