• J Minim Invasive Gynecol · Jul 2005

    Randomized Controlled Trial Clinical Trial

    Effect of bupivacaine after operative laparoscopic gynecologic procedures.

    • Temel Ceyhan, Ertan Teksoz, Sadettin Gungor, Umit Goktolga, and Recai Pabuccu.
    • Department of Obstetrics and Gynecology, Reproductive Endocrinology Unit, Gulhane Military Medical Academy and Medical School, Ankara, Turkey. stceyhan@gata.edu.tr
    • J Minim Invasive Gynecol. 2005 Jul 1;12(4):326-9.

    Study ObjectiveTo evaluate the effect of intraperitoneal installation and periportal infiltration of bupivacaine on postoperative pain and return of bowel function.DesignA prospective, double-blind, randomized trial (Canadian Task Force classification I).SettingGATA School of Medicine, Department of Obstetrics and Gynecology, Reproductive Endocrinology Unit.PatientsEighty patients undergoing operative gynecologic laparoscopy.InterventionPeriportal infiltration of local anesthesia with 10 mL 0.5% bupivacaine before incision and another 20 mL 0.5% bupivacaine diluted with 20 mL of saline or equal amount of physiologic saline injected into the peritoneal cavity at the end of the procedure.Measurements And Main ResultsEach patient recorded the severity of her pain on a visual analog scale (VAS) at 1, 6, 18, and 24 hours and the time of first bowel movement and first flatus after surgery. Seventy-seven patients completed the study (38 in the bupivacaine group; 39 in the control group). The severity of postoperative pain, as recorded on the VAS, was significantly less at 1, 6, 18, and 24 hours after surgery in the group receiving bupivacaine compared with those in the control group. The first bowel movement in the bupivacaine group occurred earlier than in the control group (284.80 +/- 31.62 min vs 453.23 +/- 33.08 min, p <.001); similarly, the first flatus occurred earlier in the bupivacaine group than in the control group (466.2 +/- 29.59 min vs 658.80 +/- 40.92 min p <.001).ConclusionIntraperitoneal installation and periportal infiltration of bupivacaine decrease postoperative pain and hasten the return of bowel function. Both decreased postoperative pain and shortened duration for the return of bowel function are crucial for comfort and discharge of the patient.

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