• Zhongguo Yi Xue Ke Xue Yuan Xue Bao · Apr 2008

    [Changes and clinical significance of serum Apelin in patients with severe sepsis and septic shock].

    • Xu-Yan Chen, Xin-Min Liu, Li-Li Feng, and Chao-Shu Tang.
    • Department of Emergency Medicine, Institute on Cardiovascular Disease Research, Peking University First Hospital, Beijing 100034, China. chenxuyan@medmail.com.cn
    • Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2008 Apr 1;30(2):131-5.

    ObjectiveTo explore the changes and clinical significance of serum Apelin in patients with severe sepsis and septic shock.MethodWe measured the serum level of Apelin with ELISA on different observation days (the 1st, 3rd, and 10th day obtaining the diagnosis) in 26 patients with severe sepsis and septic shock.ResultsSerum Apelin significantly increased in sepsis patients when compared with the normal control group (P<0.01); The serum Apelin levels significantly changed among different observation days (P< 0.01). Serum Apelin level was significantly higher in patients with septic shock than those with severe sepsis (P<0.01).ConclusionSerum Apelin level changes in patients with severe sepsis and septic shock, which may provide clues in diagnosis and prognosis.

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