• Yoshihiro Uzawa, Mikiya Otsuji, Koichi Nakazawa, Wei Fan, and Yoshitsugu Yamada.
• Department of Rehabilitation, Kameda Medical Center, 929 Higashi, Kamogawa, Chiba, 2968602, Japan. Electronic address: yoshiuzawa@yahoo.co.jp.
• Respir Physiol Neurobiol. 2015 Jan 1;205:16-20.

AbstractLung volume changes involve the recruitment of collapsed alveoli and the expansion of already opened alveoli. This study aimed to determine the alveolar recruitment function by using a mathematical model from a pressure-volume curve (P-V curve). We assumed a lung model as VL=R(P)V0f(P), where R recruitment function is the fraction of recruited alveoli, V0 is the resting lung volume at FRC of a fully recruited lung, and f(P) corresponds to the normalized compliance function of the lungs open to ventilation. Seven white rabbits were subjected to saline-lavage lung injury, and P-V curves were calculated using the slow inflation technique. We obtained the P-R curve from the P-V curve, and two curves were differently shaped after lung injury. We concluded that the recruitment function was obtained from the P-V curve and that the P-R curve estimated the recruitment and derecruitment status.Copyright © 2014 Elsevier B.V. All rights reserved.

20 keywords...

hide…