• Kennedy Inst Ethics J · Jun 2003

    Intrinsic conflicts of interest in clinical research: a need for disclosure.

    • Sharmon Sollitto, Sharona Hoffman, Maxwell Mehlman, Robert J Lederman, Stuart J Youngner, and Micheal M Lederman.
    • Case Western University School of Law, Cleveland, OH, USA.
    • Kennedy Inst Ethics J. 2003 Jun 1;13(2):83-91.

    AbstractProtection of human subjects from investigators' conflicts of interest is critical to the integrity of clinical investigation. Personal financial conflicts of interest are addressed by university policies, professional society guidelines, public standards, and government regulation, but "intrinsic conflict of interest"--conflicts of interest inherent in all clinical research--have received relatively less attention. Such conflicts arise in all clinical research endeavors as a result of the tension among professionals' responsibilities to their research and to their patients and both academic and financial incentives. These conflicts should be disclosed to research subjects and managed as assiduously as are financial conflicts of interest.

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