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Neurosci Biobehav Rev · Jul 2012
ReviewThe young brain and concussion: imaging as a biomarker for diagnosis and prognosis.
- Esteban Toledo, Alyssa Lebel, Lino Becerra, Anna Minster, Clas Linnman, Nasim Maleki, David W Dodick, and David Borsook.
- Center for Pain and the Brain, Children's Hospital Boston, Harvard Medical School, United States.
- Neurosci Biobehav Rev. 2012 Jul 1;36(6):1510-31.
AbstractConcussion (mild traumatic brain injury (mTBI)) is a significant pediatric public health concern. Despite increased awareness, a comprehensive understanding of the acute and chronic effects of concussion on central nervous system structure and function remains incomplete. Here we review the definition, epidemiology, and sequelae of concussion within the developing brain, during childhood and adolescence, with current data derived from studies of pathophysiology and neuroimaging. These findings may contribute to a better understanding of the neurological consequences of traumatic brain injuries, which in turn, may lead to the development of brain biomarkers to improve identification, management and prognosis of pediatric patients suffering from concussion.Copyright © 2012 Elsevier Ltd. All rights reserved.
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