• Eur J Gynaecol Oncol · Jan 2007

    Review Case Reports

    "Occult" neuroendocrine component and rare metastatic pattern in cervical cancer: report of a case and brief review of the literature.

    • K Rhiem, M Possover, A Gossmann, K Drebber, P Mallmann, and U Ulrich.
    • Department of Obstetrics and Gynecology, University of Cologne School of Medicine, Cologne, Germany.
    • Eur J Gynaecol Oncol. 2007 Jan 1;28(2):139-41.

    AbstractDistant metastases in small cell carcinomas of the uterine cervix are rare, and a disseminated manifestation of the disease is uncommon. This is a case report of a 40-year-old woman treated with platin-based radio-chemotherapy for a moderately differentiated squamous cell cervical cancer FIGO Stage IB 1 (with positive paraaortic lymph nodes). One year later she presented with remarkably unusual cutaneous metastases of the left thumb and scalp as the first signs of spread of disease, including kidney, lung and brain metastases. An advanced retrospective immunohistochemical staining of the cervical biopsy discovered a small neuroendocrine component of the carcinoma as the presumably causative factor for the rare metastastic pattern and poor prognosis.

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