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J Neuropsychiatry Clin Neurosci · Jan 2012
Randomized Controlled TrialA randomized, double-blind trial of repetitive transcranial magnetic stimulation in obsessive-compulsive disorder with three-month follow-up.
- Pablo Vinicius Oliveira Gomes, Joaquim Pereira Brasil-Neto, Nasser Allam, and Everton Rodrigues de Souza.
- Biology Institute, Laboratory of Neurosciences and Behavior, Brasilia University, Brasilia, Brazil.
- J Neuropsychiatry Clin Neurosci. 2012 Jan 1;24(4):437-43.
AbstractRecent findings indicate that the motor and premotor cortices are hyperexcitable in obsessive-compulsive disorder (OCD). The authors have performed the first randomized, double-blind clinical trial of repetitive transcranial magnetic stimulation (rTMS) in OCD, with a 3-month follow-up. OCD patients (N=22) were assigned to either 2 weeks of active or sham rTMS to the supplementary motor area bilaterally. After 14 weeks, the response rate was 41% (7/12) with active and 10% (1/10) with sham treatment. At 14 weeks, patients receiving active rTMS showed, on average, a 35% reduction on the Y-BOCS, as compared with a 6.2% reduction in those receiving sham treatment.
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