• K J Anand and International Evidence-Based Group for Neonatal Pain.
• MD, Arkansas Children's Hospital, S-431, 800 Marshall St, Little Rock, AR 72202, USA. anandsunny@exchange.uams.edu
• Arch Pediat Adol Med. 2001 Feb 1;155(2):173-80.

ObjectiveTo develop evidence-based guidelines for preventing or treating neonatal pain and its adverse consequences. Compared with older children and adults, neonates are more sensitive to pain and vulnerable to its long-term effects. Despite the clinical importance of neonatal pain, current medical practices continue to expose infants to repetitive, acute, or prolonged pain.DesignExperts representing several different countries, professional disciplines, and practice settings used systematic reviews, data synthesis, and open discussion to develop a consensus on clinical practices that were supported by published evidence or were commonly used, the latter based on extrapolation of evidence from older age groups. A practical format was used to describe the analgesic management for specific invasive procedures and for ongoing pain in neonates.ResultsRecognition of the sources of pain and routine assessments of neonatal pain should dictate the avoidance of recurrent painful stimuli and the use of specific environmental, behavioral, and pharmacological interventions. Individualized care plans and analgesic protocols for specific clinical situations, patients, and health care settings can be developed from these guidelines. By clearly outlining areas where evidence is not available, these guidelines may also stimulate further research. To use the recommended therapeutic approaches, clinicians must be familiar with their adverse effects and the potential for drug interactions.ConclusionManagement of pain must be considered an important component of the health care provided to all neonates, regardless of their gestational age or severity of illness.

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