• J. Clin. Invest. · Aug 2003

    Review

    The enigma of sepsis.

    • Niels C Riedemann, Ren-Feng Guo, and Peter A Ward.
    • Department of Pathology, University of Michigan Medical School, 1301 Catherine Road, Ann Arbor, Michigan 48109-0602, USA.
    • J. Clin. Invest. 2003 Aug 1;112(4):460-7.

    AbstractSepsis remains a serious cause of morbidity and mortality, and the pathophysiology of the disease is not clear. The definition of the clinical manifestations of sepsis is ever evolving. This review discusses the search for effective therapeutic interventions, hurdles in translational sepsis research, and new therapies in development in current clinical trials.

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