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- P P Ng, Y K Tay, and Y C Giam.
- National Skin Centre, Singapore.
- Ann Acad Med Singap. 2000 Jan 1;29(1):114-8.
IntroductionNeonatal lupus erythematosus (NLE) presents clinically with either cutaneous lesions or cardiac involvement and is related to the transplacental passage of anti-Ro antibodies from mother to foetus. We report a series of 10 cases seen at the National Skin Centre between 1990 and 1998 including a pair of siblings.Clinical PictureThe female to male ratio was 2.3:1 and most presented with rash between 3 to 5 weeks of life while 4 had lesions at birth. Four of the 9 mothers had SLE, one was diagnosed to have a lupus-like illness, 2 had Sjogren's syndrome and the remaining two had very high ANA titres but the final diagnosis was uncertain.OutcomeThe rash resolved spontaneously by 3 to 6 months of age.
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