• Almir Pereira Souza, Piedad Natalia Henao Guerrero, Celina Tie Nishimori, Danielli Parrilha Paula, Paulo Sergio Patto Santos, Marlis Langenegger de Rezende, and Newton Nunes.
• Department of Veterinary Clinics and Surgery, Veterinary Surgery Program, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Rod. Professor Paulo Donato Castelane, s/n. CEP: 14884-900, Jaboticabal, SP., Brazil.
• J. Feline Med. Surg. 2005 Apr 1;7(2):95-100.

AbstractThe cardiopulmonary effects of desflurane and sevoflurane anesthesia were compared in cats breathing spontaneously. Heart (HR) and respiratory (RR) rates; systolic (SAP), diastolic (DAP) and mean arterial (MAP) pressures; partial pressure of end tidal carbon dioxide (PETCO2), arterial blood pH (pH), arterial partial pressure of oxygen (PaO2) and carbon dioxide (PaCO2); base deficit (BD), arterial oxygen saturation (SaO2) and bicarbonate ion concentration (HCO3) were measured. Anesthesia was induced with propofol (8+/-2.3mg/kg IV) and maintained with desflurane (GD) or sevoflurane (GS), both at 1.3 MAC. Data were analyzed by analysis of variance (ANOVA), followed by the Tukey test (P<0.05). Both anesthetics showed similar effects. HR and RR decreased when compared to the basal values, but remained constant during inhalant anesthesia and PETCO2 increased with time. Both anesthetics caused acidemia and hypercapnia, but BD stayed within normal limits. Therefore, despite reducing HR and SAP (GD) when compared to the basal values, desflurane and sevoflurane provide good stability of the cardiovascular parameters during a short period of inhalant anesthesia (T20-T60). However, both volatile anesthetics cause acute respiratory acidosis in cats breathing spontaneously.

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