• Anaesthesia · Aug 1996

    Randomized Controlled Trial Clinical Trial

    The prevention of postoperative nausea and vomiting using a combination of ondansetron and droperidol.

    • I J Wrench, J E Ward, A D Walder, and G J Hobbs.
    • University Department of Anaesthesia, Queen's Medical Centre, Nottingham.
    • Anaesthesia. 1996 Aug 1;51(8):776-8.

    AbstractWe have studied the effect of combination antiemetic therapy (ondansetron and droperidol) with morphine delivered by patient-controlled analgesia following major gynaecological surgery. Sixty patients were randomly allocated to one of three treatment regimens; ondansetron alone (4 mg bolus and 0.13 mg.ml-1 in the morphine solution), droperidol alone (1.25 mg bolus and 0.05 mg.ml-1 in the morphine solution), or both drugs in combination. For the first 12 postoperative hours, patients receiving combination therapy experienced significantly less nausea than those receiving single antiemetic therapy (p < 0.001). There was no difference between the regimens from 12 to 18 h. We conclude that a combination of ondansetron and droperidol added to morphine in a patient-controlled analgesia system reduces postoperative nausea to a greater extent than treatment with either drug alone following major gynaecological surgery.

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