• Yu Wang, Chuan-Yong Yu, Lin Huang, Franz Riederer, and Dominik Ettlin.
• Department of Neurology, Epilepsy and Headache Group, Institute of Neurology, The First Hospital of Anhui Medical University, Anhui Medical University, Jixi Road 218, Hefei 230022, China. yw4d@hotmail.com
• J Headache Pain. 2011 Aug 1; 12 (4): 497-500.

AbstractCranial nerve neuralgia usually occurs sporadically. Nonetheless, familial cases of trigeminal neuralgia are not uncommon with a reported incidence of 1-2%, suggestive of an autosomal dominant inheritance. In contrast, familial occipital neuralgia is rarely reported with only one report in the literature. We present a Chinese family with five cases of occipital and nervus intermedius neuralgia alone or in combination in three generations. All persons afflicted with occipital neuralgia have suffered from paroxysmal 'electric wave'-like pain for years. In the first generation, the father (index patient) was affected, in the second generation all his three daughters (with two sons spared) and in the third generation a daughter's male offspring is affected. This familial pattern suggests an X-linked dominant or an autosomal dominant inheritance mode.

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