• Radiology · Feb 2012

    Comparative Study

    Digital subtraction CT angiography for detection of intracranial aneurysms: comparison with three-dimensional digital subtraction angiography.

    • Li Lu, Long Jiang Zhang, Colin S Poon, Sheng Yong Wu, Chang Sheng Zhou, Song Luo, Mei Wang, and Guang Ming Lu.
    • Department of Medical Imaging, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing, Jiangsu 210002, China.
    • Radiology. 2012 Feb 1;262(2):605-12.

    PurposeTo evaluate the diagnostic accuracy of digital subtraction computed tomographic (CT) angiography in the detection of intracranial aneurysms compared with three-dimensional (3D) rotational digital subtraction angiography (DSA), as reference standard, in a large cohort in a single center.Materials And MethodsThe study was waived by the institutional review board because of its retrospective nature. A total of 513 patients clinically suspected of having or with known intracranial aneurysms and other cerebral vascular diseases underwent both digital subtraction CT angiography with a dual-source CT scanner and 3D DSA, with a median interval of 1 day; 436 patients (84.9%) had acute subarachnoid hemorrhage at presentation. The sensitivity, specificity, and accuracy of digital subtraction CT angiography in depicting aneurysm were analyzed on a per-patient and per-aneurysm basis, with 3D DSA as the reference standard. The sensitivity, specificity, and accuracy of digital subtraction CT angiography in depicting aneurysms of different diameter (ie, <3 mm, 3-5 mm, 5-10 mm, and >10 mm) and of aneurysms at different locations in the anterior and posterior circulation were calculated. Kappa statistics were calculated to quantify inter- and intrareader variability in detecting aneurysms by using digital subtraction CT angiography for 100 patients.ResultsOf 513 patients, 106 (20.7%) had no aneurysms, while 407 patients (79.3%) had 459 aneurysms at 3D DSA. Digital subtraction CT angiography correctly depicted 456 (99.3%) of the 459 aneurysms. By using 3D DSA as the standard of reference, the sensitivity and specificity of depicting intracranial aneurysms were 97.8% (398 of 407) and 88.7% (94 of 106), respectively, on a per-patient basis, and 96.5% (443 of 459) and 87.8% (94 of 107), respectively, on a per-aneurysm basis. Digital subtraction CT angiography had sensitivities of 91.3% (42 of 46), 94.0% (140 of 149), 98.4% (186 of 189), and 100% (75 of 75) in depicting aneurysms of less than 3 mm, between 3 mm but less than 5 mm, between 5 mm but less than 10 mm, and 10 mm or greater, respectively, and of 95.8% (276 of 288) and 97.7% (167 of 171) in depicting anterior circulation and posterior circulation aneurysms, respectively. Excellent inter- and intrareader agreement was found on a per-patient (κ=0.900 and 0.939, both P<.001) and per-aneurysm basis (κ=0.846 and 0.921, both P<.001) for the detection of intracranial aneurysms with digital subtraction CT angiography.ConclusionDigital subtraction CT angiography has a high sensitivity and specificity in depicting intracranial aneurysms with different sizes and at different locations, compared with 3D DSA.© RSNA, 2011

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…